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Published Aug 15, 22
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Side effects include trouble falling or staying asleep, nausea, falls, and uncontrolled, involuntary movements. that imitate the action of dopamine in the brain to treat the motor symptoms of Parkinson’s disease. Examples include pramipexole, rot ropinirole and igotine that can be taken on their own or with levodopa. Side effects can include nausea, orthostatichypotension, hallucinations, somnolence, and impulse control disorders.

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However, the main body of evidence showing that CBD has promise as an effective treatment for this disease lies in studies relating to adjunct actions and complications from the disease including oxidative stress, neural inflammation and neurodegeneration. One such study is from 2011 in which researchers published the findings of the journal Psychopharmacology.

Using an animal model of cognitive impairment induced by iron overload, they tested the effects of CBD in memory-impaired rats in both a single dose as well as continued use. In the first experimental condition, the researchers administering a single dose of either 5. 0 mg/kg or 10. 0 mg/kg of CBD immediately after a training session of the novel object recognition task.

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They found that a single dose of 10. 0 mg/kg of CBD recovered memory while repeated CBD administration of either CBD dose improved recognition memory. They concluded that the evidence suggests that CBD shows potential for the treatment of cognitive decline associated with neurodegenerative disorders. Testing the efficacy of CBD for the management and treatment of Parkinson’s disease in a double-blind, clinical trial with patients diagnosed with Parkinson’s disease, they published their findings in the Journal of Psychopharmacology in 2014.

The control group was treated with a placebo, the first experimental group with 75 mg/day of CBD and the second experimental group with 300 mg/day of CBD. Participants were assessed in respect to motor and general symptoms, well-being and quality of life, and possible neuroprotective effects one week before and again, during the last week of treatment.

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However, the researchers also noted that studies with larger samples and specific objectives are required before definitive conclusions can be drawn. In contrast, the latest research from 2020 suggests that CBD can help with motor symptoms, specifically tremors. In the Journal of Psychopharmacology, researchers published the results from their study aimed at evaluating the impact of a single dose of 300 mg CBD on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with Parkinson’s disease.



In a 2015 study published in Toxicology in Vitro, scientists investigated the potential neurorestorative effects of CBD and the pathways that mediate it for the treatment of Parkinson’s disease. They used rat neurons treated with a neurotoxin that is known to induce Parkinson's disease in vivo and presents with neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced neurotrophic support.

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The data indicated that CBD has neuroprotective effects on neural cells that involves neuritogenesis, NGF receptors as well as an increased expression of axonal and synaptic proteins leading them to conclude that the neuroprotective effects of CBD might be beneficial in Parkinson's disease. Anecdotal Evidence - using CBD oil for Parkinson's The scientific evidence seems to indicate that CBD has the potential to improve quality of life for patients with Parkinson’s disease in addition to reducing neuroinflammation and oxidative stress as well as induce neurogenesis and neuritogenesis that can potentially slow or even reverse disease progression.

In fact, according to this study, while only 4. 3% of a self-report survey of patients with Parkinson’s disease used cannabis, it ranked among the most effective complimentary and alternative therapies listed. CBD as a complementary treatment for Parkinson's CBD can also play a role as a complementary therapy to help reduce many of the symptoms associated with the pharmaceutical treatments usually prescribed to patients with Parkinson’s disease.

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Likewise, CBD has specifically been shown to help improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder as well as psychosis in Parkinson’s disease patients. Bottom Line The anti-inflammatory, anti-oxidative, neuroprotective and neuroregenaritive effects of CBD can all prove to make it a promising treatment for Parkinson’s disease, for both symptom reduction as well as even potentially slowing down disease progression.